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DAB2 peptide

 
 
Company: Creative Diagnostics
City: Shirley
Country: United States Of America
Type: 
Sell
Country: 
United States Of America
City: 
Shirley
Company: 
Creative Diagnostics

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] https://www.creative-diagnostics.com/DAB2-peptide-176898-427.htm

 
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